Microenvironmental Influence on Pre-Clinical Activity of Polo-Like Kinase Inhibition in Multiple Myeloma: Implications for Clinical Translation

Douglas W. McMillin; Jake Delmore; Joseph Negri; Melissa Ooi; Steffen Klippel; Chandrasekhar V. Miduturu; Nathanael S. Gray; Paul G. Richardson; Kenneth C. Anderson; Andrew L. Kung; Constantine S. Mitsiades

doi:10.1371/journal.pone.0020226

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Open Access

Peer-reviewed

Research Article

Microenvironmental Influence on Pre-Clinical Activity of Polo-Like Kinase Inhibition in Multiple Myeloma: Implications for Clinical Translation

Douglas W. McMillin,

Affiliations Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Jake Delmore,

Affiliations Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Joseph Negri,

Affiliations Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Melissa Ooi,

Affiliations Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Steffen Klippel,

Affiliations Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Chandrasekhar V. Miduturu,

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Department of Cancer Biology and Harvard Medical School, Boston, Massachusetts, United States of America
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Nathanael S. Gray,

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Department of Cancer Biology and Harvard Medical School, Boston, Massachusetts, United States of America
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Paul G. Richardson,

Affiliations Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Kenneth C. Anderson,

Affiliations Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Andrew L. Kung,

Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Boston, Massachusetts, United States of America
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Constantine S. Mitsiades

* E-mail: Constantine_Mitsiades@dfci.harvard.edu

Affiliations Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Microenvironmental Influence on Pre-Clinical Activity of Polo-Like Kinase Inhibition in Multiple Myeloma: Implications for Clinical Translation

Douglas W. McMillin,
Jake Delmore,
Joseph Negri,
Melissa Ooi,
Steffen Klippel,
Chandrasekhar V. Miduturu,
Nathanael S. Gray,
Paul G. Richardson,
Kenneth C. Anderson,
Andrew L. Kung

Published: July 7, 2011
https://doi.org/10.1371/journal.pone.0020226

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