Novel Polymorphisms in Plasmodium falciparum ABC Transporter Genes Are Associated with Major ACT Antimalarial Drug Resistance

Maria Isabel Veiga; Pedro Eduardo Ferreira; Louise Jörnhagen; Maja Malmberg; Aminatou Kone; Berit Aydin Schmidt; Max Petzold; Anders Björkman; Francois Nosten; Jose Pedro Gil

doi:10.1371/journal.pone.0020212

Loading metrics

Open Access

Peer-reviewed

Research Article

Novel Polymorphisms in Plasmodium falciparum ABC Transporter Genes Are Associated with Major ACT Antimalarial Drug Resistance

Maria Isabel Veiga ,

* E-mail: Isabel.veiga@ki.se

Affiliations Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Drug Resistance and Pharmacogenetics Group, Centre of Molecular and Structural Biomedicine, Institute of Biotechnology and Bioengineering, University of Algarve, Faro, Portugal
⨯
Pedro Eduardo Ferreira,

Affiliations Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Drug Resistance and Pharmacogenetics Group, Centre of Molecular and Structural Biomedicine, Institute of Biotechnology and Bioengineering, University of Algarve, Faro, Portugal
⨯
Louise Jörnhagen,

Affiliation Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
⨯
Maja Malmberg,

Affiliation Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
⨯
Aminatou Kone,

Affiliation Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
⨯
Berit Aydin Schmidt,

Affiliation Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
⨯
Max Petzold,

Affiliation Nordic School of Public Health, Gothenburg, Sweden
⨯
Anders Björkman,

Affiliation Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
⨯
Francois Nosten,

Affiliations Shoklo Malaria Research Unit, Mae Sot Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Nuffield Department of Clinical Medicine, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom
⨯
Jose Pedro Gil

Affiliations Drug Resistance and Pharmacogenetics Group, Centre of Molecular and Structural Biomedicine, Institute of Biotechnology and Bioengineering, University of Algarve, Faro, Portugal, Division of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden,, Laboratory of Molecular Anthropology and Health, Department of Anthropology, Binghamton University, Binghamton, New York, United States of America
⨯

Novel Polymorphisms in Plasmodium falciparum ABC Transporter Genes Are Associated with Major ACT Antimalarial Drug Resistance

Maria Isabel Veiga,
Pedro Eduardo Ferreira,
Louise Jörnhagen,
Maja Malmberg,
Aminatou Kone,
Berit Aydin Schmidt,
Max Petzold,
Anders Björkman,
Francois Nosten,
Jose Pedro Gil

Published: May 25, 2011
https://doi.org/10.1371/journal.pone.0020212

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Antimalarials
Is the Subject Area "Antimalarials" applicable to this article?

Thanks for your feedback.
Antimicrobial resistance
Is the Subject Area "Antimicrobial resistance" applicable to this article?

Thanks for your feedback.
Copy number variation
Is the Subject Area "Copy number variation" applicable to this article?

Thanks for your feedback.
Artemisinin
Is the Subject Area "Artemisinin" applicable to this article?

Thanks for your feedback.
Crystal structure
Is the Subject Area "Crystal structure" applicable to this article?

Thanks for your feedback.
Malaria
Is the Subject Area "Malaria" applicable to this article?

Thanks for your feedback.
Plasmodium
Is the Subject Area "Plasmodium" applicable to this article?

Thanks for your feedback.
Single nucleotide polymorphisms
Is the Subject Area "Single nucleotide polymorphisms" applicable to this article?

Thanks for your feedback.