Targeted Skipping of Human Dystrophin Exons in Transgenic Mouse Model Systemically for Antisense Drug Development

Bo Wu; Ehsan Benrashid; Peijuan Lu; Caryn Cloer; Allen Zillmer; Mona Shaban; Qi Long Lu

doi:10.1371/journal.pone.0019906

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Open Access

Peer-reviewed

Research Article

Targeted Skipping of Human Dystrophin Exons in Transgenic Mouse Model Systemically for Antisense Drug Development

Bo Wu ,

Contributed equally to this work with: Bo Wu, Ehsan Benrashid

* E-mail: qi.lu@carolinashealthcare.org (QLL); bo.wu@carolinashealthcare.org (BW)

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Neuromuscular/ALS Center, Department of Neurology, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Ehsan Benrashid ,

Contributed equally to this work with: Bo Wu, Ehsan Benrashid

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Neuromuscular/ALS Center, Department of Neurology, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Peijuan Lu,

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Neuromuscular/ALS Center, Department of Neurology, Carolinas Medical Center, Charlotte, North Carolina, United States of America
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Caryn Cloer,

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Neuromuscular/ALS Center, Department of Neurology, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Allen Zillmer,

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Neuromuscular/ALS Center, Department of Neurology, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Mona Shaban,

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Neuromuscular/ALS Center, Department of Neurology, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Qi Long Lu

* E-mail: qi.lu@carolinashealthcare.org (QLL); bo.wu@carolinashealthcare.org (BW)

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Neuromuscular/ALS Center, Department of Neurology, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯

Targeted Skipping of Human Dystrophin Exons in Transgenic Mouse Model Systemically for Antisense Drug Development

Bo Wu,
Ehsan Benrashid,
Peijuan Lu,
Caryn Cloer,
Allen Zillmer,
Mona Shaban,
Qi Long Lu

Published: May 17, 2011
https://doi.org/10.1371/journal.pone.0019906

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01 Jun 2011
20:23 GMT
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Acknowledgement Posted by qilu on 01 Jun 2011 at 20:23 GMT

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Dystrophin
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Myoblasts
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Mouse models
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Reverse transcriptase-polymerase chain reaction
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Cardiac muscles
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Drug research and development
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