Interferon-α/β and Anti-Fibroblast Growth Factor Receptor 1 Monoclonal Antibody Suppress Hepatic Cancer Cells In Vitro and In Vivo

Shigeru Sasaki; Tadao Ishida; Minoru Toyota; Akinobu Ota; Hiromu Suzuki; Akinori Takaoka; Hiroshi Yasui; Hiroyuki Yamamoto; Hideyasu Takagi; Masahiro Maeda; Tsutomu Seito; Masayuki Tsujisaki; Yasuhisa Shinomura; Kohzoh Imai

doi:10.1371/journal.pone.0019618

Loading metrics

Open Access

Peer-reviewed

Research Article

Interferon-α/β and Anti-Fibroblast Growth Factor Receptor 1 Monoclonal Antibody Suppress Hepatic Cancer Cells In Vitro and In Vivo

Shigeru Sasaki ,

* E-mail: ssasaki@sapmed.ac.jp (SS); mtoyota@sapmed.ac.jp (MT)

Affiliation First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
⨯
Tadao Ishida,

Affiliation First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
⨯
Minoru Toyota ,

* E-mail: ssasaki@sapmed.ac.jp (SS); mtoyota@sapmed.ac.jp (MT)

Affiliation Department of Molecular Biology, Sapporo Medical University, Sapporo, Japan
⨯
Akinobu Ota,

Affiliation Immuno-Biological Laboratories Co., Ltd., Fujioka, Japan
⨯
Hiromu Suzuki,

Affiliations First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan, Department of Molecular Biology, Sapporo Medical University, Sapporo, Japan
⨯
Akinori Takaoka,

Affiliation Division of Signaling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
⨯
Hiroshi Yasui,

Affiliations First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan, Department of Molecular Biology, Sapporo Medical University, Sapporo, Japan
⨯
Hiroyuki Yamamoto,

Affiliation First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
⨯
Hideyasu Takagi,

Affiliation First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
⨯
Masahiro Maeda,

Affiliation Immuno-Biological Laboratories Co., Ltd., Fujioka, Japan
⨯
Tsutomu Seito,

Affiliation Immuno-Biological Laboratories Co., Ltd., Fujioka, Japan
⨯
Masayuki Tsujisaki,

Affiliation Department of Gastroenterology and Hematology, Tenshi Hospital, Sapporo, Japan
⨯
Yasuhisa Shinomura,

Affiliation First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
⨯
Kohzoh Imai

Affiliation Division of Novel Therapy for Cancer, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⨯

Interferon-α/β and Anti-Fibroblast Growth Factor Receptor 1 Monoclonal Antibody Suppress Hepatic Cancer Cells In Vitro and In Vivo

Shigeru Sasaki,
Tadao Ishida,
Minoru Toyota,
Akinobu Ota,
Hiromu Suzuki,
Akinori Takaoka,
Hiroshi Yasui,
Hiroyuki Yamamoto,
Hideyasu Takagi,
Masahiro Maeda

Published: May 9, 2011
https://doi.org/10.1371/journal.pone.0019618

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Hepatocellular carcinoma
Is the Subject Area "Hepatocellular carcinoma" applicable to this article?

Thanks for your feedback.
Malignant tumors
Is the Subject Area "Malignant tumors" applicable to this article?

Thanks for your feedback.
Interferons
Is the Subject Area "Interferons" applicable to this article?

Thanks for your feedback.
Fibroblast growth factor
Is the Subject Area "Fibroblast growth factor" applicable to this article?

Thanks for your feedback.
Antibody therapy
Is the Subject Area "Antibody therapy" applicable to this article?

Thanks for your feedback.
Immunohistochemistry techniques
Is the Subject Area "Immunohistochemistry techniques" applicable to this article?

Thanks for your feedback.