Genetic Diversity of Near Genome-Wide Hepatitis C Virus Sequences during Chronic Infection: Evidence for Protein Structural Conservation Over Time

Hui Li; Austin L. Hughes; Nazneen Bano; Susan McArdle; Stephen Livingston; Heike Deubner; Brian J. McMahon; Lisa Townshend-Bulson; Rachel McMahan; Hugo R. Rosen; David R. Gretch

doi:10.1371/journal.pone.0019562

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Peer-reviewed

Research Article

Genetic Diversity of Near Genome-Wide Hepatitis C Virus Sequences during Chronic Infection: Evidence for Protein Structural Conservation Over Time

Hui Li,

Affiliation Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America
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Austin L. Hughes,

Affiliation Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, United States of America
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Nazneen Bano,

Affiliation Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America
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Susan McArdle,

Affiliation Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America
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Stephen Livingston,

Affiliation Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, Alaska, United States of America
⨯
Heike Deubner,

Affiliation Department of Pathology, University of Washington Medical Center, Seattle, Washington, United States of America
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Brian J. McMahon,

Affiliation Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, Alaska, United States of America
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Lisa Townshend-Bulson,

Affiliation Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, Alaska, United States of America
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Rachel McMahan,

Affiliation Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America
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Hugo R. Rosen,

Affiliation Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
David R. Gretch

* E-mail: gretch@u.washington.edu

Affiliations Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington Medical Center, Seattle, Washington, United States of America
⨯

Genetic Diversity of Near Genome-Wide Hepatitis C Virus Sequences during Chronic Infection: Evidence for Protein Structural Conservation Over Time

Hui Li,
Austin L. Hughes,
Nazneen Bano,
Susan McArdle,
Stephen Livingston,
Heike Deubner,
Brian J. McMahon,
Lisa Townshend-Bulson,
Rachel McMahan,
Hugo R. Rosen

Published: May 5, 2011
https://doi.org/10.1371/journal.pone.0019562

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Hepatitis C virus
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Nucleotides
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Fibrosis
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Genomics
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Microbial mutation
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Deletion mutation
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Protein sequencing
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