DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAs

Ah-Young So; Ji-Won Jung; Seunghee Lee; Hyung-Sik Kim; Kyung-Sun Kang

doi:10.1371/journal.pone.0019503

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Peer-reviewed

Research Article

DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAs

Ah-Young So ,

Contributed equally to this work with: Ah-Young So, Ji-Won Jung, Seunghee Lee

Affiliations Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea, Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
⨯
Ji-Won Jung ,

Contributed equally to this work with: Ah-Young So, Ji-Won Jung, Seunghee Lee

Affiliation Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Chungbuk, Republic of Korea
⨯
Seunghee Lee ,

Contributed equally to this work with: Ah-Young So, Ji-Won Jung, Seunghee Lee

Affiliations Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea, Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
⨯
Hyung-Sik Kim,

Affiliations Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea, Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
⨯
Kyung-Sun Kang

* E-mail: kangpub@snu.ac.kr

Affiliations Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea, Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
⨯

DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAs

Ah-Young So,
Ji-Won Jung,
Seunghee Lee,
Hyung-Sik Kim,
Kyung-Sun Kang

Published: May 10, 2011
https://doi.org/10.1371/journal.pone.0019503

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DNA methylation
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MicroRNAs
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Histones
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Promoter regions
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Genomics
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Epigenetics
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Gene expression
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Mesenchymal stem cells
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