Acyclic Identification of Aptamers for Human alpha-Thrombin Using Over-Represented Libraries and Deep Sequencing

Open Access

Peer-reviewed

Research Article

Gillian V. Kupakuwana,

Affiliation Graduate Program in Structural Biology, Biochemistry and Biophysics, Syracuse University, Syracuse, New York, United States of America
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James E. Crill II,

Affiliation AptaMatrix, Inc., Syracuse, New York, United States of America
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Mark P. McPike,

Affiliation AptaMatrix, Inc., Syracuse, New York, United States of America
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Philip N. Borer

* E-mail: pnborer@syr.edu

Affiliations Graduate Program in Structural Biology, Biochemistry and Biophysics, Syracuse University, Syracuse, New York, United States of America, AptaMatrix, Inc., Syracuse, New York, United States of America, Department of Chemistry, Syracuse University, Syracuse, New York, United States of America
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Sequence motif analysis
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Thrombin
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DNA libraries
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Polymerase chain reaction
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Thrombin signaling
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Chemical synthesis
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Gel electrophoresis
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Nucleotide sequencing
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