Abcg2 Overexpression Represents a Novel Mechanism for Acquired Resistance to the Multi-Kinase Inhibitor Danusertib in BCR-ABL-Positive Cells In Vitro

Stefan Balabanov; Artur Gontarewicz; Gunhild Keller; Laura Raddrizzani; Melanie Braig; Roberta Bosotti; Jürgen Moll; Edgar Jost; Christine Barett; Imke Rohe; Carsten Bokemeyer; Tessa L. Holyoake; Tim H. Brümmendorf

doi:10.1371/journal.pone.0019164

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Peer-reviewed

Research Article

Abcg2 Overexpression Represents a Novel Mechanism for Acquired Resistance to the Multi-Kinase Inhibitor Danusertib in BCR-ABL-Positive Cells In Vitro

Stefan Balabanov ,

Contributed equally to this work with: Stefan Balabanov, Artur Gontarewicz

Affiliation Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Universitäres Cancer Center Hamburg (UCCH), Universitäts-Klinikum Hamburg-Eppendorf, Hamburg, Germany
⨯
Artur Gontarewicz ,

Contributed equally to this work with: Stefan Balabanov, Artur Gontarewicz

Affiliation Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Universitäres Cancer Center Hamburg (UCCH), Universitäts-Klinikum Hamburg-Eppendorf, Hamburg, Germany
⨯
Gunhild Keller,

Affiliation Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Universitäres Cancer Center Hamburg (UCCH), Universitäts-Klinikum Hamburg-Eppendorf, Hamburg, Germany
⨯
Laura Raddrizzani,

Affiliation Nerviano Medical Sciences - Oncology, Nerviano, Milan, Italy
⨯
Melanie Braig,

Affiliation Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Universitäres Cancer Center Hamburg (UCCH), Universitäts-Klinikum Hamburg-Eppendorf, Hamburg, Germany
⨯
Roberta Bosotti,

Affiliation Nerviano Medical Sciences - Oncology, Nerviano, Milan, Italy
⨯
Jürgen Moll,

Affiliation Nerviano Medical Sciences - Oncology, Nerviano, Milan, Italy
⨯
Edgar Jost,

Affiliation Klinik für Hämatologie und Onkologie, Medizinische Klinik IV, Universitätsklinikum Aachen, Rheinisch Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany
⨯
Christine Barett,

Affiliation Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Universitäres Cancer Center Hamburg (UCCH), Universitäts-Klinikum Hamburg-Eppendorf, Hamburg, Germany
⨯
Imke Rohe,

Affiliation Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Universitäres Cancer Center Hamburg (UCCH), Universitäts-Klinikum Hamburg-Eppendorf, Hamburg, Germany
⨯
Carsten Bokemeyer,

Affiliation Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Universitäres Cancer Center Hamburg (UCCH), Universitäts-Klinikum Hamburg-Eppendorf, Hamburg, Germany
⨯
Tessa L. Holyoake,

Affiliation Section of Experimental Haematology and Haemopoietic Stem Cells, University of Glasgow, Glasgow, United Kingdom
⨯
Tim H. Brümmendorf

* E-mail: tbruemmendorf@ukaachen.de

Affiliations Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Universitäres Cancer Center Hamburg (UCCH), Universitäts-Klinikum Hamburg-Eppendorf, Hamburg, Germany, Klinik für Hämatologie und Onkologie, Medizinische Klinik IV, Universitätsklinikum Aachen, Rheinisch Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany
⨯

Abcg2 Overexpression Represents a Novel Mechanism for Acquired Resistance to the Multi-Kinase Inhibitor Danusertib in BCR-ABL-Positive Cells In Vitro

Stefan Balabanov,
Artur Gontarewicz,
Gunhild Keller,
Laura Raddrizzani,
Melanie Braig,
Roberta Bosotti,
Jürgen Moll,
Edgar Jost,
Christine Barett,
Imke Rohe

Published: April 26, 2011
https://doi.org/10.1371/journal.pone.0019164

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