Defective CFTR-Dependent CREB Activation Results in Impaired Spermatogenesis and Azoospermia

Wen Ming Xu; Jing Chen; Hui Chen; Rui Ying Diao; Kin Lam Fok; Jian Da Dong; Ting Ting Sun; Wen Ying Chen; Mei Kuen Yu; Xiao Hu Zhang; Lai Ling Tsang; Ann Lau; Qi Xian Shi; Qing Hua Shi; Ping Bo Huang; Hsiao Chang Chan

doi:10.1371/journal.pone.0019120

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Peer-reviewed

Research Article

Defective CFTR-Dependent CREB Activation Results in Impaired Spermatogenesis and Azoospermia

Wen Ming Xu ,

Contributed equally to this work with: Wen Ming Xu, Jing Chen

Affiliations Sichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China, Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
⨯
Jing Chen ,

Contributed equally to this work with: Wen Ming Xu, Jing Chen

Affiliation Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
⨯
Hui Chen,

Affiliation Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
⨯
Rui Ying Diao,

Affiliations Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China, Shenzhen Key Lab of Male Reproduction and Genetics, Peking University Shenzhen Hospital, Shenzhen, People's Republic of China
⨯
Kin Lam Fok,

Affiliation Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
⨯
Jian Da Dong,

Affiliation Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
⨯
Ting Ting Sun,

Affiliation Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
⨯
Wen Ying Chen,

Affiliations Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China, Department of Reproductive Physiology, Zhejiang Academy of Medical Sciences, Hangzhou, People's Republic of China
⨯
Mei Kuen Yu,

Affiliation Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
⨯
Xiao Hu Zhang,

Affiliation Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
⨯
Lai Ling Tsang,

Affiliation Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
⨯
Ann Lau,

Affiliation Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
⨯
Qi Xian Shi,

Affiliation Department of Reproductive Physiology, Zhejiang Academy of Medical Sciences, Hangzhou, People's Republic of China
⨯
Qing Hua Shi,

Affiliation Laboratory of Molecular and Cell Genetics, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, People's Republic of China
⨯
Ping Bo Huang,

Affiliation Department of Biology, Hong Kong University of Science and Technology, Hong Kong, People's Republic of China
⨯
[ ... ],
Hsiao Chang Chan

* E-mail: hsiaocchan@cuhk.edu.hk

Affiliations Sichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China, Faculty of Medicine, School of Biomedical Sciences, Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
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Defective CFTR-Dependent CREB Activation Results in Impaired Spermatogenesis and Azoospermia

Wen Ming Xu,
Jing Chen,
Hui Chen,
Rui Ying Diao,
Kin Lam Fok,
Jian Da Dong,
Ting Ting Sun,
Wen Ying Chen,
Mei Kuen Yu,
Xiao Hu Zhang

Published: May 9, 2011
https://doi.org/10.1371/journal.pone.0019120

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