Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network

Baoshan Xu; Sujuan Chen; Yan Luo; Zi Chen; Lei Liu; Hongyu Zhou; Wenxing Chen; Tao Shen; Xiuzhen Han; Long Chen; Shile Huang

doi:10.1371/journal.pone.0019052

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Peer-reviewed

Research Article

Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network

Baoshan Xu ,

Contributed equally to this work with: Baoshan Xu, Sujuan Chen

Affiliation Department of Biochemistry and Molecular Biology, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Sujuan Chen ,

Contributed equally to this work with: Baoshan Xu, Sujuan Chen

Affiliation Department of Biochemistry and Molecular Biology, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Yan Luo,

Affiliation Department of Biochemistry and Molecular Biology, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Zi Chen,

Affiliation Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, People's Republic of China
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Lei Liu,

Affiliation Department of Biochemistry and Molecular Biology, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
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Hongyu Zhou,

Affiliation Department of Biochemistry and Molecular Biology, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
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Wenxing Chen,

Affiliation Department of Biochemistry and Molecular Biology, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
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Tao Shen,

Affiliation Department of Biochemistry and Molecular Biology, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
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Xiuzhen Han,

Affiliation Department of Biochemistry and Molecular Biology, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
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Long Chen ,

* E-mail: shuan1@lsuhsc.edu (SH); lchen@njnu.edu.cn (LC)

Affiliation Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, People's Republic of China
⨯
Shile Huang

* E-mail: shuan1@lsuhsc.edu (SH); lchen@njnu.edu.cn (LC)

Affiliation Department of Biochemistry and Molecular Biology, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯

Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network

Baoshan Xu,
Sujuan Chen,
Yan Luo,
Zi Chen,
Lei Liu,
Hongyu Zhou,
Wenxing Chen,
Tao Shen,
Xiuzhen Han,
Long Chen

Published: April 22, 2011
https://doi.org/10.1371/journal.pone.0019052

Reader Comments (2)

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12 May 2011
15:13 GMT
Most Recent

Use of Ca-chelators and Ca-fluorescence dye in cadmium studies is not appropriate Posted by fthevenod on 12 May 2011 at 15:13 GMT
0 Responses

04 May 2011
16:47 GMT
Most Recent

Publisher's Note: Error in affiliation assignment Posted by PLOS_ONE_Group on 04 May 2011 at 16:47 GMT

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Apoptosis
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MAPK signaling cascades
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Neurons
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Calcium signaling
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Neuronal death
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Cell viability testing
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Reactive oxygen species
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Homeostasis
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