Isolation and Mutagenesis of a Capsule-Like Complex (CLC) from Francisella tularensis, and Contribution of the CLC to F. tularensis Virulence in Mice

Aloka B. Bandara; Anna E. Champion; Xiaoshan Wang; Gretchen Berg; Michael A. Apicella; Molly McLendon; Parastoo Azadi; D. Scott Snyder; Thomas J. Inzana

doi:10.1371/journal.pone.0019003

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Research Article

Isolation and Mutagenesis of a Capsule-Like Complex (CLC) from Francisella tularensis, and Contribution of the CLC to F. tularensis Virulence in Mice

Aloka B. Bandara ,

Contributed equally to this work with: Aloka B. Bandara, Anna E. Champion

Affiliation Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
⨯
Anna E. Champion ,

Contributed equally to this work with: Aloka B. Bandara, Anna E. Champion

Affiliation Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
⨯
Xiaoshan Wang,

Current address: Biochain, Hayward, California, United States of America

Affiliation Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
⨯
Gretchen Berg,

Current address: Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

Affiliation Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
⨯
Michael A. Apicella,

Affiliation Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
⨯
Molly McLendon,

Affiliation Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
⨯
Parastoo Azadi,

Affiliation Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America
⨯
D. Scott Snyder,

Affiliation Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America
⨯
Thomas J. Inzana

* E-mail: tinzana@vt.edu

Affiliation Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
⨯

Isolation and Mutagenesis of a Capsule-Like Complex (CLC) from Francisella tularensis, and Contribution of the CLC to F. tularensis Virulence in Mice

Aloka B. Bandara,
Anna E. Champion,
Xiaoshan Wang,
Gretchen Berg,
Michael A. Apicella,
Molly McLendon,
Parastoo Azadi,
D. Scott Snyder,
Thomas J. Inzana

Published: April 22, 2011
https://doi.org/10.1371/journal.pone.0019003

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Francisella tularensis
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Carbohydrates
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Polymerase chain reaction
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Electrophoretic staining
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Protein extraction
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