A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication and Unfolding/Translocation of the Cholera Toxin A1 Subunit

Michael Taylor; Tuhina Banerjee; Fernando Navarro-Garcia; Jazmin Huerta; Shane Massey; Mansfield Burlingame; Abhay H. Pande; Suren A. Tatulian; Ken Teter

doi:10.1371/journal.pone.0018825

Loading metrics

Open Access

Peer-reviewed

Research Article

A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication and Unfolding/Translocation of the Cholera Toxin A1 Subunit

Michael Taylor ,

Contributed equally to this work with: Michael Taylor, Tuhina Banerjee

Affiliation Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America
⨯
Tuhina Banerjee ,

Contributed equally to this work with: Michael Taylor, Tuhina Banerjee

Affiliation Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America
⨯
Fernando Navarro-Garcia,

Affiliation Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-Zacatenco), México City, Mexico
⨯
Jazmin Huerta,

Affiliation Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-Zacatenco), México City, Mexico
⨯
Shane Massey,

Current address: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America

Affiliation Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America
⨯
Mansfield Burlingame,

Current address: Lake Brantley High School, Altamonte Springs, Florida, United States of America

Affiliation Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America
⨯
Abhay H. Pande,

Current address: Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sec-67, S.A.S. Nagar, Mohali, India

Affiliation Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America
⨯
Suren A. Tatulian,

Affiliation Department of Physics, University of Central Florida, Orlando, Florida, United States of America
⨯
Ken Teter

* E-mail: kteter@mail.ucf.edu

Affiliation Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America
⨯

A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication and Unfolding/Translocation of the Cholera Toxin A1 Subunit

Michael Taylor,
Tuhina Banerjee,
Fernando Navarro-Garcia,
Jazmin Huerta,
Shane Massey,
Mansfield Burlingame,
Abhay H. Pande,
Suren A. Tatulian,
Ken Teter

Published: April 19, 2011
https://doi.org/10.1371/journal.pone.0018825

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Toxins
Is the Subject Area "Toxins" applicable to this article?

Thanks for your feedback.
Cytosol
Is the Subject Area "Cytosol" applicable to this article?

Thanks for your feedback.
Intoxication
Is the Subject Area "Intoxication" applicable to this article?

Thanks for your feedback.
Fluorescence spectroscopy
Is the Subject Area "Fluorescence spectroscopy" applicable to this article?

Thanks for your feedback.
Cholera
Is the Subject Area "Cholera" applicable to this article?

Thanks for your feedback.
Endoplasmic reticulum
Is the Subject Area "Endoplasmic reticulum" applicable to this article?

Thanks for your feedback.
HeLa cells
Is the Subject Area "HeLa cells" applicable to this article?

Thanks for your feedback.
Fluorescence
Is the Subject Area "Fluorescence" applicable to this article?

Thanks for your feedback.