AGEs Decrease Insulin Synthesis in Pancreatic β-Cell by Repressing Pdx-1 Protein Expression at the Post-Translational Level

Open Access

Peer-reviewed

Research Article

Tingting Shu ,

Contributed equally to this work with: Tingting Shu, Yunxia Zhu

Affiliation Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yunxia Zhu ,

Contributed equally to this work with: Tingting Shu, Yunxia Zhu

Affiliation Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Hongdong Wang,

Affiliation Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yan Lin,

Affiliation Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Zhuo Ma,

Affiliation Hubei University of Technology, Wuhan, Hubei, China
⨯
Xiao Han

* E-mail: hanxiao@njmu.edu.cn

Affiliation Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
⨯

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Insulin
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Protein expression
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Transcription factors
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Messenger RNA
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Protein synthesis
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Transcriptional control
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Diabetes mellitus
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Oxidative stress
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