Separase Phosphosite Mutation Leads to Genome Instability and Primordial Germ Cell Depletion during Oogenesis

Open Access

Peer-reviewed

Research Article

Juan Xu ,

Contributed equally to this work with: Juan Xu, Meizhi Wang

Affiliation Model Animal Research Center, Nanjing University, Nanjing, China
⨯
Meizhi Wang ,

Contributed equally to this work with: Juan Xu, Meizhi Wang

Affiliation Department of Anatomy, Histology and Embryology, Southern Medical University, Guangzhou, China
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Xinxing Gao,

Affiliation Model Animal Research Center, Nanjing University, Nanjing, China
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Bian Hu,

Affiliation Model Animal Research Center, Nanjing University, Nanjing, China
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Yinan Du,

Affiliation Model Animal Research Center, Nanjing University, Nanjing, China
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Jiankui Zhou,

Affiliation Model Animal Research Center, Nanjing University, Nanjing, China
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Xuemei Tian ,

* E-mail: xmtian05@yahoo.com (XT); huangxingxu@yahoo.com (XH)

Affiliation School of Life Science, South China Normal University, Guangzhou, China
⨯
Xingxu Huang

* E-mail: xmtian05@yahoo.com (XT); huangxingxu@yahoo.com (XH)

Affiliation Model Animal Research Center, Nanjing University, Nanjing, China
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Point mutation
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Gonads
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Aneuploidy
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Mouse models
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Embryos
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Quantitative analysis
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