Gamma-Secretase Inhibitor Treatment Promotes VEGF-A-Driven Blood Vessel Growth and Vascular Leakage but Disrupts Neovascular Perfusion

• Mattias Kalén,

  Affiliation Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden

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• Tommi Heikura ,

  Contributed equally to this work with: Tommi Heikura, Henna Karvinen

  Affiliation Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

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• Henna Karvinen ,

  Contributed equally to this work with: Tommi Heikura, Henna Karvinen

  Affiliation Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

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• Anja Nitzsche,

  Affiliation Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden

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• Holger Weber,

  Affiliation ProQinase GmbH, Freiburg, Germany

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• Norbert Esser,

  Affiliation ProQinase GmbH, Freiburg, Germany

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• Seppo Ylä-Herttuala,

  Affiliation Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

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• Mats Hellström

  * E-mail: mats.hellstrom@igp.uu.se

  Affiliation Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden

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