Small Molecule Amiloride Modulates Oncogenic RNA Alternative Splicing to Devitalize Human Cancer Cells

• Jan-Gowth Chang ,

  * E-mail: wkyang@mail.cmu.edu.tw (W-KY); jgchang@ms.kmuh.org.tw (J-GC)

  Affiliations Department of Medical Research, University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

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• Den-Mei Yang †,

  † Deceased.

  Affiliation Cell/Gene Therapy Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

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• Wen-Hsin Chang,

  Affiliation Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Lu-Ping Chow,

  Affiliation Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Wen-Ling Chan,

  Affiliations Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan

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• Hui-Hua Lin,

  Affiliations Department of Medical Research, University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Hsien-Da Huang,

  Affiliations Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan

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• Ya-Sian Chang,

  Affiliation Department of Medical Research, University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Cheng-Hao Hung,

  Affiliation Cell/Gene Therapy Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

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• Wen-Kuang Yang

  * E-mail: wkyang@mail.cmu.edu.tw (W-KY); jgchang@ms.kmuh.org.tw (J-GC)

  Affiliations Cell/Gene Therapy Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, Departments of Biochemistry and Medicine, China Medical University, Taichung, Taiwan

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