Replication Stress Induces Micronuclei Comprising of Aggregated DNA Double-Strand Breaks

Bing Xu; Zhaoliang Sun; Zhaojian Liu; Haiyang Guo; Qiao Liu; Haiyan Jiang; Yongxin Zou; Yaoqin Gong; Jay A. Tischfield; Changshun Shao

doi:10.1371/journal.pone.0018618

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Open Access

Peer-reviewed

Research Article

Replication Stress Induces Micronuclei Comprising of Aggregated DNA Double-Strand Breaks

Bing Xu,

Affiliation Key Laboratory of Experimental Teratology, Ministry of Education, and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong, China
⨯
Zhaoliang Sun,

Affiliation Key Laboratory of Experimental Teratology, Ministry of Education, and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong, China
⨯
Zhaojian Liu,

Affiliation Key Laboratory of Experimental Teratology, Ministry of Education, and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong, China
⨯
Haiyang Guo,

Affiliation Key Laboratory of Experimental Teratology, Ministry of Education, and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong, China
⨯
Qiao Liu,

Affiliation Key Laboratory of Experimental Teratology, Ministry of Education, and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong, China
⨯
Haiyan Jiang,

Affiliation Key Laboratory of Experimental Teratology, Ministry of Education, and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong, China
⨯
Yongxin Zou,

Affiliation Key Laboratory of Experimental Teratology, Ministry of Education, and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong, China
⨯
Yaoqin Gong,

Affiliation Key Laboratory of Experimental Teratology, Ministry of Education, and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong, China
⨯
Jay A. Tischfield,

Affiliation Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Changshun Shao

* E-mail: changshun.shao@gmail.com

Affiliations Key Laboratory of Experimental Teratology, Ministry of Education, and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong, China, Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America
⨯

Replication Stress Induces Micronuclei Comprising of Aggregated DNA Double-Strand Breaks

Bing Xu,
Zhaoliang Sun,
Zhaojian Liu,
Haiyang Guo,
Qiao Liu,
Haiyan Jiang,
Yongxin Zou,
Yaoqin Gong,
Jay A. Tischfield,
Changshun Shao

Published: April 15, 2011
https://doi.org/10.1371/journal.pone.0018618

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DNA replication
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Synthesis phase
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Cell cycle and cell division
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Micronuclei
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