Influence of Dll4 via HIF-1α-VEGF Signaling on the Angiogenesis of Choroidal Neovascularization under Hypoxic Conditions

Xiao Dong; Yu-Sheng Wang; Guo-Rui Dou; Hui-Yuan Hou; Yuan-Yuan Shi; Rui Zhang; Ke Ma; Lin Wu; Li-Bo Yao; Yan Cai; Jian Zhang

doi:10.1371/journal.pone.0018481

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Open Access

Peer-reviewed

Research Article

Influence of Dll4 via HIF-1α-VEGF Signaling on the Angiogenesis of Choroidal Neovascularization under Hypoxic Conditions

Xiao Dong,

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Yu-Sheng Wang ,

* E-mail: wangys003@126.com (Y-SW); biozhangj@yahoo.com.cn (JZ)

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Guo-Rui Dou,

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Hui-Yuan Hou,

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Yuan-Yuan Shi,

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Rui Zhang,

Affiliation Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Ke Ma,

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Lin Wu,

Affiliation Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Li-Bo Yao,

Affiliation Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Yan Cai,

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Jian Zhang

* E-mail: wangys003@126.com (Y-SW); biozhangj@yahoo.com.cn (JZ)

Affiliation Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, People's Republic of China
⨯

Influence of Dll4 via HIF-1α-VEGF Signaling on the Angiogenesis of Choroidal Neovascularization under Hypoxic Conditions

Xiao Dong,
Yu-Sheng Wang,
Guo-Rui Dou,
Hui-Yuan Hou,
Yuan-Yuan Shi,
Rui Zhang,
Ke Ma,
Lin Wu,
Li-Bo Yao,
Yan Cai

Published: April 19, 2011
https://doi.org/10.1371/journal.pone.0018481

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Hypoxia
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Angiogenesis
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Notch signaling
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VEGF signaling
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Transfection
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Medical hypoxia
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Cell migration
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Reverse transcriptase-polymerase chain reaction
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