R5-SHIV Induces Multiple Defects in T Cell Function during Early Infection of Rhesus Macaques Including Accumulation of T Reg Cells in Lymph Nodes

Michael Santosuosso; Elda Righi; E. David Hill; Pierre R. Leblanc; Brett Kodish; Hari N. Mylvaganam; Nagadenahalli B. Siddappa; Liljana Stevceva; Shiu-Lok Hu; Musie Ghebremichael; Agnes-L. Chenine; Avi-Hai Hovav; Ruth M. Ruprecht; Mark C. Poznansky

doi:10.1371/journal.pone.0018465

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Peer-reviewed

Research Article

R5-SHIV Induces Multiple Defects in T Cell Function during Early Infection of Rhesus Macaques Including Accumulation of T Reg Cells in Lymph Nodes

Michael Santosuosso,

Affiliation Infectious Diseases Medicine Division, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Elda Righi,

Affiliation Infectious Diseases Medicine Division, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
E. David Hill,

Affiliation Infectious Diseases Medicine Division, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Pierre R. Leblanc,

Affiliation Infectious Diseases Medicine Division, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Brett Kodish,

Affiliation Infectious Diseases Medicine Division, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Hari N. Mylvaganam,

Affiliation Infectious Diseases Medicine Division, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Nagadenahalli B. Siddappa,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Liljana Stevceva,

Affiliation Infectious Diseases Medicine Division, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Shiu-Lok Hu,

Affiliation Department of Pharmaceutics, University of Washington, Seattle, Washington, United States of America
⨯
Musie Ghebremichael,

Affiliation Department of Biostatistics and Computational Biology, Harvard School of Public Health and Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Agnes-L. Chenine,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Avi-Hai Hovav,

Affiliation Faculty of Dental Medicine, Institute of Dental Sciences, Hebrew University, Jerusalem, Israel
⨯
Ruth M. Ruprecht,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Mark C. Poznansky

* E-mail: mpoznansky@partners.org

Affiliation Infectious Diseases Medicine Division, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯

R5-SHIV Induces Multiple Defects in T Cell Function during Early Infection of Rhesus Macaques Including Accumulation of T Reg Cells in Lymph Nodes

Michael Santosuosso,
Elda Righi,
E. David Hill,
Pierre R. Leblanc,
Brett Kodish,
Hari N. Mylvaganam,
Nagadenahalli B. Siddappa,
Liljana Stevceva,
Shiu-Lok Hu,
Musie Ghebremichael

Published: April 5, 2011
https://doi.org/10.1371/journal.pone.0018465

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