IKKβ Regulates the Repair of DNA Double-Strand Breaks Induced by Ionizing Radiation in MCF-7 Breast Cancer Cells

Lixian Wu; Lijian Shao; Ningfei An; Junru Wang; Senthil Pazhanisamy; Wei Feng; Martin Hauer-Jensen; Shigeki Miyamoto; Daohong Zhou

doi:10.1371/journal.pone.0018447

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Open Access

Peer-reviewed

Research Article

IKKβ Regulates the Repair of DNA Double-Strand Breaks Induced by Ionizing Radiation in MCF-7 Breast Cancer Cells

Lixian Wu ,

Contributed equally to this work with: Lixian Wu, Lijian Shao

Affiliations Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, Department of Pharmacology, Fujian Medical University, Fuzhou, China
⨯
Lijian Shao ,

Contributed equally to this work with: Lixian Wu, Lijian Shao

Affiliation Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
⨯
Ningfei An,

Affiliation Department of Pathology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Junru Wang,

Affiliation Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
⨯
Senthil Pazhanisamy,

Affiliation Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
⨯
Wei Feng,

Affiliation Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
⨯
Martin Hauer-Jensen,

Affiliations Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States of America
⨯
Shigeki Miyamoto,

Affiliation Department of Pharmacology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Daohong Zhou

* E-mail: dzhou@uams.edu

Affiliation Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
⨯

IKKβ Regulates the Repair of DNA Double-Strand Breaks Induced by Ionizing Radiation in MCF-7 Breast Cancer Cells

Lixian Wu,
Lijian Shao,
Ningfei An,
Junru Wang,
Senthil Pazhanisamy,
Wei Feng,
Martin Hauer-Jensen,
Shigeki Miyamoto,
Daohong Zhou

Published: April 7, 2011
https://doi.org/10.1371/journal.pone.0018447

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DNA repair
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Immunofluorescence staining
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Transfection
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Breast cancer
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Cell staining
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Small interfering RNA
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Cancer treatment
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Lung and intrathoracic tumors
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