Uremic Toxins Inhibit Transport by Breast Cancer Resistance Protein and Multidrug Resistance Protein 4 at Clinically Relevant Concentrations

Henricus A. M. Mutsaers; Lambertus P. van den Heuvel; Lauke H. J. Ringens; Anita C. A. Dankers; Frans G. M. Russel; Jack F. M. Wetzels; Joost G. Hoenderop; Rosalinde Masereeuw

doi:10.1371/journal.pone.0018438

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Open Access

Peer-reviewed

Research Article

Uremic Toxins Inhibit Transport by Breast Cancer Resistance Protein and Multidrug Resistance Protein 4 at Clinically Relevant Concentrations

Henricus A. M. Mutsaers,

Affiliations Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands, Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Lambertus P. van den Heuvel,

Affiliations Department of Pediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Department of Pediatrics, Catholic University Leuven, Leuven, Belgium
⨯
Lauke H. J. Ringens,

Affiliation Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Anita C. A. Dankers,

Affiliation Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Frans G. M. Russel,

Affiliation Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Jack F. M. Wetzels,

Affiliation Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Joost G. Hoenderop,

Affiliation Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Rosalinde Masereeuw

* E-mail: r.masereeuw@pharmtox.umcn.nl

Affiliation Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯

Uremic Toxins Inhibit Transport by Breast Cancer Resistance Protein and Multidrug Resistance Protein 4 at Clinically Relevant Concentrations

Henricus A. M. Mutsaers,
Lambertus P. van den Heuvel,
Lauke H. J. Ringens,
Anita C. A. Dankers,
Frans G. M. Russel,
Jack F. M. Wetzels,
Joost G. Hoenderop,
Rosalinde Masereeuw

Published: April 4, 2011
https://doi.org/10.1371/journal.pone.0018438

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