Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding

Jeong Joo Kim; Darren E. Casteel; Gilbert Huang; Taek Hun Kwon; Ronnie Kuo Ren; Peter Zwart; Jeffrey J. Headd; Nicholas Gene Brown; Dar-Chone Chow; Timothy Palzkill; Choel Kim

doi:10.1371/journal.pone.0018413

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Research Article

Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding

Jeong Joo Kim,

Affiliation Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Darren E. Casteel,

Affiliation Department of Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Gilbert Huang,

Affiliation The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Taek Hun Kwon,

Affiliation Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Ronnie Kuo Ren,

Affiliation Rice University, Houston, Texas, United States of America
⨯
Peter Zwart,

Affiliation The Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
⨯
Jeffrey J. Headd,

Affiliation Computational Crystallography Initiative, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
⨯
Nicholas Gene Brown,

Affiliation The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Dar-Chone Chow,

Affiliation The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Timothy Palzkill,

Affiliations Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America, The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Choel Kim

* E-mail: ckim@bcm.edu

Affiliations Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America, The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding

Jeong Joo Kim,
Darren E. Casteel,
Gilbert Huang,
Taek Hun Kwon,
Ronnie Kuo Ren,
Peter Zwart,
Jeffrey J. Headd,
Nicholas Gene Brown,
Dar-Chone Chow,
Timothy Palzkill

Published: April 19, 2011
https://doi.org/10.1371/journal.pone.0018413

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