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Open Access

Peer-reviewed

Research Article

Global Gene Expression Profiling of Endothelium Exposed to Heme Reveals an Organ-Specific Induction of Cytoprotective Enzymes in Sickle Cell Disease

Samit Ghosh ,

Contributed equally to this work with: Samit Ghosh, Fang Tan

Affiliation Aflac Cancer Center and Blood Disorders Service, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Fang Tan ,

Contributed equally to this work with: Samit Ghosh, Fang Tan

Affiliation Aflac Cancer Center and Blood Disorders Service, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Tianwei Yu,

Affiliation Department of Biostatics and Bioinformatics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Yuhua Li,

Affiliation Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Olufolake Adisa,

Affiliation Aflac Cancer Center and Blood Disorders Service, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Mario Mosunjac,

Affiliation Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Solomon F. Ofori-Acquah

* E-mail: soforia@emory.edu

Affiliations Aflac Cancer Center and Blood Disorders Service, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America, Center for Endothelial Biology, Children's Healthcare of Atlanta, Atlanta, Georgia, United States of America
⨯

Global Gene Expression Profiling of Endothelium Exposed to Heme Reveals an Organ-Specific Induction of Cytoprotective Enzymes in Sickle Cell Disease

Samit Ghosh,
Fang Tan,
Tianwei Yu,
Yuhua Li,
Olufolake Adisa,
Mario Mosunjac,
Solomon F. Ofori-Acquah

x

Published: March 31, 2011
https://doi.org/10.1371/journal.pone.0018399

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Heme
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Endothelial cells
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Endothelium
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Gene expression
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Genetically modified animals
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Lungs
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