Hedgehog Inhibition Promotes a Switch from Type II to Type I Cell Death Receptor Signaling in Cancer Cells

Open Access

Peer-reviewed

Research Article

Satoshi Kurita,

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Justin L. Mott,

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Sophie C. Cazanave,

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Christian D. Fingas,

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Maria E. Guicciardi,

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Steve F. Bronk,

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Lewis R. Roberts,

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Martin E. Fernandez-Zapico,

Affiliations Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Gregory J. Gores

* E-mail: gores.gregory@mayo.edu

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

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Apoptosis
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Hedgehog signaling
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Cholangiocarcinoma
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Small interfering RNA
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Signal inhibition
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Mitochondria
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Transfection
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Cytotoxicity
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