Recombinant Complement Receptor 2 Radiolabeled with [99mTc(CO)3]+ : A Potential New Radiopharmaceutical for Imaging Activated Complement

Adam Badar; Sarah DeFreitas; James M. McDonnell; Norhakim Yahya; David Thakor; Reza Razavi; Richard Smith; Steven Sacks; Gregory E. D. Mullen

doi:10.1371/journal.pone.0018275

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Peer-reviewed

Research Article

Recombinant Complement Receptor 2 Radiolabeled with [^99mTc(CO)₃]⁺ : A Potential New Radiopharmaceutical for Imaging Activated Complement

Adam Badar ,

Contributed equally to this work with: Adam Badar, Sarah DeFreitas

Affiliations Medical Research Council Centre for Transplantation, King's College London, Guy's Hospital, London, United Kingdom, Division of Imaging Sciences, King's College London, St. Thomas' Hospital, London, United Kingdom
⨯
Sarah DeFreitas ,

Contributed equally to this work with: Adam Badar, Sarah DeFreitas

Affiliation Medical Research Council Centre for Transplantation, King's College London, Guy's Hospital, London, United Kingdom
⨯
James M. McDonnell,

Affiliation Randall Division of Cell & Molecular Biophysics, New Hunt's House, King's College London, London, United Kingdom
⨯
Norhakim Yahya,

Affiliation Randall Division of Cell & Molecular Biophysics, New Hunt's House, King's College London, London, United Kingdom
⨯
David Thakor,

Affiliation Division of Imaging Sciences, King's College London, St. Thomas' Hospital, London, United Kingdom
⨯
Reza Razavi,

Affiliation Division of Imaging Sciences, King's College London, St. Thomas' Hospital, London, United Kingdom
⨯
Richard Smith,

Affiliation Medical Research Council Centre for Transplantation, King's College London, Guy's Hospital, London, United Kingdom
⨯
Steven Sacks ,

* E-mail: stephen.sacks@kcl.ac.uk (SS); greg.mullen@kcl.ac.uk (GEDM)

Affiliation Medical Research Council Centre for Transplantation, King's College London, Guy's Hospital, London, United Kingdom
⨯
Gregory E. D. Mullen

* E-mail: stephen.sacks@kcl.ac.uk (SS); greg.mullen@kcl.ac.uk (GEDM)

Affiliations Medical Research Council Centre for Transplantation, King's College London, Guy's Hospital, London, United Kingdom, Division of Imaging Sciences, King's College London, St. Thomas' Hospital, London, United Kingdom
⨯

Recombinant Complement Receptor 2 Radiolabeled with [^99mTc(CO)₃]⁺ : A Potential New Radiopharmaceutical for Imaging Activated Complement

Adam Badar,
Sarah DeFreitas,
James M. McDonnell,
Norhakim Yahya,
David Thakor,
Reza Razavi,
Richard Smith,
Steven Sacks,
Gregory E. D. Mullen

Published: April 6, 2011
https://doi.org/10.1371/journal.pone.0018275

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Radiolabeling
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Complement activation
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Enzyme-linked immunoassays
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Recombinant proteins
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Binding analysis
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Cell binding
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Red blood cells
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Complement receptors
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