Trafficking Defect and Proteasomal Degradation Contribute to the Phenotype of a Novel KCNH2 Long QT Syndrome Mutation

Open Access

Peer-reviewed

Research Article

Anton Mihic,

Affiliation Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada
⨯
Vijay S. Chauhan,

Affiliation Division of Cardiology, University Health Network, Toronto, Ontario, Canada
⨯
Xiaodong Gao,

Affiliation Department of Biology, York University, Toronto, Ontario, Canada
⨯
Gavin Y. Oudit ,

* E-mail: gavin.oudit@ualberta.ca (GYO); tsushima@yorku.ca (RGT)

Affiliation Department of Medicine, Mazankowski Alberta Heart Institute and Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
⨯
Robert G. Tsushima

* E-mail: gavin.oudit@ualberta.ca (GYO); tsushima@yorku.ca (RGT)

Affiliation Department of Biology, York University, Toronto, Ontario, Canada
⨯

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Protein expression
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Frameshift mutation
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Transfection
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Membrane proteins
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Cell membranes
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Co-immunoprecipitation
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Point mutation
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Electrophysiology
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