Glucose and Fatty Acids Synergize to Promote B-Cell Apoptosis through Activation of Glycogen Synthase Kinase 3β Independent of JNK Activation

Katsuya Tanabe; Yang Liu; Syed D. Hasan; Sara C. Martinez; Corentin Cras-Méneur; Cris M. Welling; Ernesto Bernal-Mizrachi; Yukio Tanizawa; Christopher J. Rhodes; Erik Zmuda; Tsonwin Hai; Nada A. Abumrad; M. Alan Permutt

doi:10.1371/journal.pone.0018146

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Peer-reviewed

Research Article

Glucose and Fatty Acids Synergize to Promote B-Cell Apoptosis through Activation of Glycogen Synthase Kinase 3β Independent of JNK Activation

Katsuya Tanabe,

Affiliation Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Yang Liu,

Affiliation Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Syed D. Hasan,

Affiliation Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Sara C. Martinez,

Affiliation Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Corentin Cras-Méneur,

Affiliation Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Cris M. Welling,

Affiliation Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Ernesto Bernal-Mizrachi,

Affiliation Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Yukio Tanizawa,

Affiliation Division of Endocrinology, Metabolism, Hematological Sciences and Therapeutics Department of Bio-Signal Analysis, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
⨯
Christopher J. Rhodes,

Affiliation Department of Medicine, Kovler Diabetes Center, University of Chicago, Chicago, Illinois, United States of America
⨯
Erik Zmuda,

Affiliation Department of Molecular and Cellular Biochemistry, Center for Molecular Neurobiology, Ohio State University, Columbus, Ohio, United States of America
⨯
Tsonwin Hai,

Affiliation Department of Molecular and Cellular Biochemistry, Center for Molecular Neurobiology, Ohio State University, Columbus, Ohio, United States of America
⨯
Nada A. Abumrad,

Affiliation Division of Nutritional Science, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
M. Alan Permutt

* E-mail: apermutt@dom.wustl.edu

Affiliation Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Glucose and Fatty Acids Synergize to Promote B-Cell Apoptosis through Activation of Glycogen Synthase Kinase 3β Independent of JNK Activation

Katsuya Tanabe,
Yang Liu,
Syed D. Hasan,
Sara C. Martinez,
Corentin Cras-Méneur,
Cris M. Welling,
Ernesto Bernal-Mizrachi,
Yukio Tanizawa,
Christopher J. Rhodes,
Erik Zmuda

Published: April 26, 2011
https://doi.org/10.1371/journal.pone.0018146

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