Structural Asymmetry of Phosphodiesterase-9, Potential Protonation of a Glutamic Acid, and Role of the Invariant Glutamine

• Jing Hou,

  Affiliation Structural Biology Lab, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China

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• Jie Xu,

  Affiliation Structural Biology Lab, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China

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• Ming Liu,

  Affiliation Structural Biology Lab, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China

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• Ruizhi Zhao,

  Affiliation Structural Biology Lab, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China

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• Hai-Bin Luo ,

  * E-mail: hke@med.unc.edu (HK); luohb77@mail.sysu.edu.cn (H-BL)

  Affiliation Structural Biology Lab, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China

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• Hengming Ke

  * E-mail: hke@med.unc.edu (HK); luohb77@mail.sysu.edu.cn (H-BL)

  Affiliations Structural Biology Lab, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China, Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, North Carolina, United States of America

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