Activated Protein Synthesis and Suppressed Protein Breakdown Signaling in Skeletal Muscle of Critically Ill Patients

Jakob G. Jespersen; Anders Nedergaard; Søren Reitelseder; Ulla R. Mikkelsen; Kasper J. Dideriksen; Jakob Agergaard; Frederik Kreiner; Frank C. Pott; Peter Schjerling; Michael Kjaer

doi:10.1371/journal.pone.0018090

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Open Access

Peer-reviewed

Research Article

Activated Protein Synthesis and Suppressed Protein Breakdown Signaling in Skeletal Muscle of Critically Ill Patients

Jakob G. Jespersen ,

* E-mail: jespersen.jakob@gmail.com

Affiliation Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Anders Nedergaard,

Affiliation Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Søren Reitelseder,

Affiliation Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Ulla R. Mikkelsen,

Affiliation Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Kasper J. Dideriksen,

Affiliation Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Jakob Agergaard,

Affiliation Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Frederik Kreiner,

Affiliation Department of Rheumatology, Institute of Inflammation Research, Rigshospitalet, Copenhagen, Denmark
⨯
Frank C. Pott,

Affiliation Department of Anesthesiology, Bispebjerg Hospital, Copenhagen, Denmark
⨯
Peter Schjerling,

Affiliation Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Michael Kjaer

Affiliation Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯

Activated Protein Synthesis and Suppressed Protein Breakdown Signaling in Skeletal Muscle of Critically Ill Patients

Jakob G. Jespersen,
Anders Nedergaard,
Søren Reitelseder,
Ulla R. Mikkelsen,
Kasper J. Dideriksen,
Jakob Agergaard,
Frederik Kreiner,
Frank C. Pott,
Peter Schjerling,
Michael Kjaer

Published: March 31, 2011
https://doi.org/10.1371/journal.pone.0018090

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02 Oct 2011
21:44 GMT
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Comment on Jespersen et al. (PLoS ONE 6: e18090, 2011) Posted by Jakob_Jespersen on 02 Oct 2011 at 21:44 GMT

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Intensive care units
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Skeletal muscles
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Muscle proteins
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Insulin
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Biopsy
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Muscle protein synthesis
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Insulin signaling
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Protein synthesis
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