The Ras Antagonist, Farnesylthiosalicylic Acid (FTS), Decreases Fibrosis and Improves Muscle Strength in dy2J/dy2J Mouse Model of Muscular Dystrophy

Yoram Nevo; Shlomit Aga-Mizrachi; Edva Elmakayes; Nurit Yanay; Keren Ettinger; Moran Elbaz; Zivia Brunschwig; Oshrat Dadush; Galit Elad-Sfadia; Roni Haklai; Yoel Kloog; Joab Chapman; Shimon Reif

doi:10.1371/journal.pone.0018049

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Research Article

The Ras Antagonist, Farnesylthiosalicylic Acid (FTS), Decreases Fibrosis and Improves Muscle Strength in dy^2J/dy^2J Mouse Model of Muscular Dystrophy

Yoram Nevo ,

Contributed equally to this work with: Yoram Nevo, Shlomit Aga-Mizrachi

* E-mail: nevo@hadassah.org.il

Affiliation Pediatric Neuromuscular Laboratory and the Neuropediatric Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
⨯
Shlomit Aga-Mizrachi ,

Contributed equally to this work with: Yoram Nevo, Shlomit Aga-Mizrachi

Affiliation Pediatric Neuromuscular Laboratory and the Neuropediatric Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
⨯
Edva Elmakayes,

Affiliation Pediatric Neuromuscular Laboratory and the Neuropediatric Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
⨯
Nurit Yanay,

Affiliation Pediatric Neuromuscular Laboratory and the Neuropediatric Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
⨯
Keren Ettinger,

Affiliation Pediatric Neuromuscular Laboratory and the Neuropediatric Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
⨯
Moran Elbaz,

Affiliation Pediatric Neuromuscular Laboratory and the Neuropediatric Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
⨯
Zivia Brunschwig,

Affiliation Pediatric Neuromuscular Laboratory and the Neuropediatric Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
⨯
Oshrat Dadush,

Affiliation Pediatric Neuromuscular Laboratory and the Neuropediatric Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
⨯
Galit Elad-Sfadia,

Affiliation Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel
⨯
Roni Haklai,

Affiliation Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel
⨯
Yoel Kloog,

Affiliation Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel
⨯
Joab Chapman,

Affiliation Department of Neurology, Sheba Medical Center, Tel-Aviv University, Tel-Aviv, Israel
⨯
Shimon Reif

Affiliation Pediatric Department, Dana Children's Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel
⨯

The Ras Antagonist, Farnesylthiosalicylic Acid (FTS), Decreases Fibrosis and Improves Muscle Strength in dy^2J/dy^2J Mouse Model of Muscular Dystrophy

Yoram Nevo,
Shlomit Aga-Mizrachi,
Edva Elmakayes,
Nurit Yanay,
Keren Ettinger,
Moran Elbaz,
Zivia Brunschwig,
Oshrat Dadush,
Galit Elad-Sfadia,
Roni Haklai

Published: March 22, 2011
https://doi.org/10.1371/journal.pone.0018049

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Fibrosis
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Collagens
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Fast-twitch muscle fibers
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Muscular dystrophies
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