Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis

Akira Mima; Hideharu Abe; Kojiro Nagai; Hidenori Arai; Takeshi Matsubara; Makoto Araki; Kazuo Torikoshi; Tatsuya Tominaga; Noriyuki Iehara; Atsushi Fukatsu; Toru Kita; Toshio Doi

doi:10.1371/journal.pone.0017929

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Open Access

Peer-reviewed

Research Article

Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis

Akira Mima,

Affiliations Department of Nephrology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan, Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Hideharu Abe ,

* E-mail: abeabe@clin.med.tokushima-u.ac.jp

Affiliation Department of Nephrology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
⨯
Kojiro Nagai,

Affiliation Department of Nephrology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
⨯
Hidenori Arai,

Affiliation Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Takeshi Matsubara,

Affiliation Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Makoto Araki,

Affiliation Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Kazuo Torikoshi,

Affiliation Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Tatsuya Tominaga,

Affiliation Department of Nephrology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
⨯
Noriyuki Iehara,

Affiliation Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Atsushi Fukatsu,

Affiliation Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Toru Kita,

Affiliation Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Toshio Doi

Affiliation Department of Nephrology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
⨯

Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis

Akira Mima,
Hideharu Abe,
Kojiro Nagai,
Hidenori Arai,
Takeshi Matsubara,
Makoto Araki,
Kazuo Torikoshi,
Tatsuya Tominaga,
Noriyuki Iehara,
Atsushi Fukatsu

Published: March 22, 2011
https://doi.org/10.1371/journal.pone.0017929

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Glomerulonephritis
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SMAD signaling
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Phosphorylation
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Small interfering RNA
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Signal transduction
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Transfection
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Glomeruli
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Immunoprecipitation
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