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Open Access

Peer-reviewed

Research Article

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow

C. Andrew Boswell ,

* E-mail: boswell.andy@gene.com

Affiliation Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc., South San Francisco, California, United States of America
⨯
Gregory Z. Ferl,

Affiliation Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc., South San Francisco, California, United States of America
⨯
Eduardo E. Mundo,

Affiliation Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc., South San Francisco, California, United States of America
⨯
Daniela Bumbaca,

Affiliation Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc., South San Francisco, California, United States of America
⨯
Michelle G. Schweiger,

Affiliation Department of Investigative Safety Assessment, Genentech Inc., South San Francisco, California, United States of America
⨯
Frank-Peter Theil,

Affiliation Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc., South San Francisco, California, United States of America
⨯
Paul J. Fielder,

Affiliation Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc., South San Francisco, California, United States of America
⨯
Leslie A. Khawli

Affiliation Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc., South San Francisco, California, United States of America
⨯

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow

C. Andrew Boswell,
Gregory Z. Ferl,
Eduardo E. Mundo,
Daniela Bumbaca,
Michelle G. Schweiger,
Frank-Peter Theil,
Paul J. Fielder,
Leslie A. Khawli

x

Published: March 15, 2011
https://doi.org/10.1371/journal.pone.0017874

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