Serum Markers of Hepatocyte Death and Apoptosis Are Non Invasive Biomarkers of Severe Fibrosis in Patients with Alcoholic Liver Disease

Vanessa Jeannette Lavallard; Stéphanie Bonnafous; Stéphanie Patouraux; Marie-Christine Saint-Paul; Déborah Rousseau; Rodolphe Anty; Yannick Le Marchand-Brustel; Albert Tran; Philippe Gual

doi:10.1371/journal.pone.0017599

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Peer-reviewed

Research Article

Serum Markers of Hepatocyte Death and Apoptosis Are Non Invasive Biomarkers of Severe Fibrosis in Patients with Alcoholic Liver Disease

Vanessa Jeannette Lavallard ,

Contributed equally to this work with: Vanessa Jeannette Lavallard, Stéphanie Bonnafous

Affiliations Team 8, ≪Hepatic complications of obesity≫, INSERM, U895, Nice, France, Faculty of Medicine, University of Nice-Sophia-Antipolis, Nice, France, Digestive Center, Centre Hospitalier Universitaire of Nice, Nice, France
⨯
Stéphanie Bonnafous ,

Contributed equally to this work with: Vanessa Jeannette Lavallard, Stéphanie Bonnafous

Affiliations Team 8, ≪Hepatic complications of obesity≫, INSERM, U895, Nice, France, Digestive Center, Centre Hospitalier Universitaire of Nice, Nice, France
⨯
Stéphanie Patouraux,

Affiliations Team 8, ≪Hepatic complications of obesity≫, INSERM, U895, Nice, France, Faculty of Medicine, University of Nice-Sophia-Antipolis, Nice, France, Biological Center, Centre Hospitalier Universitaire of Nice, Nice, France
⨯
Marie-Christine Saint-Paul,

Affiliations Team 8, ≪Hepatic complications of obesity≫, INSERM, U895, Nice, France, Faculty of Medicine, University of Nice-Sophia-Antipolis, Nice, France, Biological Center, Centre Hospitalier Universitaire of Nice, Nice, France
⨯
Déborah Rousseau,

Affiliations Team 8, ≪Hepatic complications of obesity≫, INSERM, U895, Nice, France, Faculty of Medicine, University of Nice-Sophia-Antipolis, Nice, France
⨯
Rodolphe Anty,

Affiliations Team 8, ≪Hepatic complications of obesity≫, INSERM, U895, Nice, France, Faculty of Medicine, University of Nice-Sophia-Antipolis, Nice, France, Digestive Center, Centre Hospitalier Universitaire of Nice, Nice, France
⨯
Yannick Le Marchand-Brustel,

Affiliations Team 8, ≪Hepatic complications of obesity≫, INSERM, U895, Nice, France, Faculty of Medicine, University of Nice-Sophia-Antipolis, Nice, France, Digestive Center, Centre Hospitalier Universitaire of Nice, Nice, France
⨯
Albert Tran,

Affiliations Team 8, ≪Hepatic complications of obesity≫, INSERM, U895, Nice, France, Faculty of Medicine, University of Nice-Sophia-Antipolis, Nice, France, Digestive Center, Centre Hospitalier Universitaire of Nice, Nice, France
⨯
Philippe Gual

* E-mail: gual@unice.fr

Affiliations Team 8, ≪Hepatic complications of obesity≫, INSERM, U895, Nice, France, Faculty of Medicine, University of Nice-Sophia-Antipolis, Nice, France, Digestive Center, Centre Hospitalier Universitaire of Nice, Nice, France
⨯

Serum Markers of Hepatocyte Death and Apoptosis Are Non Invasive Biomarkers of Severe Fibrosis in Patients with Alcoholic Liver Disease

Vanessa Jeannette Lavallard,
Stéphanie Bonnafous,
Stéphanie Patouraux,
Marie-Christine Saint-Paul,
Déborah Rousseau,
Rodolphe Anty,
Yannick Le Marchand-Brustel,
Albert Tran,
Philippe Gual

Published: March 18, 2011
https://doi.org/10.1371/journal.pone.0017599

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Apoptosis
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Fibrosis
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Necrotic cell death
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Hepatocytes
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