p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms

Open Access

Peer-reviewed

Research Article

p16^INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms

Yuanyuan Li,

Affiliation Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Trygve O. Tollefsbol

* E-mail: trygve@uab.edu

Affiliations Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Center for Aging, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Epigenetics
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Fibroblasts
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Glucose
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Senescence
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Gene regulation
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Chromatin
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Aging
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Gene expression
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