Deep Sequencing of the Nicastrin Gene in Pooled DNA, the Identification of Genetic Variants That Affect Risk of Alzheimer's Disease

Michelle K. Lupton; Petroula Proitsi; Makrina Danillidou; Magda Tsolaki; Gillian Hamilton; Richard Wroe; Megan Pritchard; Kathryn Lord; Belinda M. Martin; Iwona Kloszewska; Hilkka Soininen; Patrizia Mecocci; Bruno Vellas; Denise Harold; Paul Hollingworth; Simon Lovestone; John F. Powell

doi:10.1371/journal.pone.0017298

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Peer-reviewed

Research Article

Deep Sequencing of the Nicastrin Gene in Pooled DNA, the Identification of Genetic Variants That Affect Risk of Alzheimer's Disease

Michelle K. Lupton ,

* E-mail: michelle.lupton@kcl.ac.uk

Affiliation MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London, United Kingdom
⨯
Petroula Proitsi,

Affiliation MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London, United Kingdom
⨯
Makrina Danillidou,

Affiliation 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
⨯
Magda Tsolaki,

Affiliation 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
⨯
Gillian Hamilton,

Affiliation Medical Genetics, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom
⨯
Richard Wroe,

Affiliation MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London, United Kingdom
⨯
Megan Pritchard,

Affiliation MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London, United Kingdom
⨯
Kathryn Lord,

Affiliation MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London, United Kingdom
⨯
Belinda M. Martin,

Affiliation MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London, United Kingdom
⨯
Iwona Kloszewska,

Affiliation Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland
⨯
Hilkka Soininen,

Affiliation Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
⨯
Patrizia Mecocci,

Affiliation Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
⨯
Bruno Vellas,

Affiliation Department of Internal and Geriatrics Medicine, Hôpitaux de Toulouse, Toulouse, France
⨯
Denise Harold,

Affiliation Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom
⨯
Paul Hollingworth,

Affiliation Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom
⨯
Simon Lovestone,

Affiliation MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London, United Kingdom
⨯
[ ... ],
John F. Powell

Affiliation MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London, United Kingdom
⨯
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Deep Sequencing of the Nicastrin Gene in Pooled DNA, the Identification of Genetic Variants That Affect Risk of Alzheimer's Disease

Michelle K. Lupton,
Petroula Proitsi,
Makrina Danillidou,
Magda Tsolaki,
Gillian Hamilton,
Richard Wroe,
Megan Pritchard,
Kathryn Lord,
Belinda M. Martin,
Iwona Kloszewska

Published: February 25, 2011
https://doi.org/10.1371/journal.pone.0017298

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Single nucleotide polymorphisms
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Alzheimer's disease
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Genotyping
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Polymerase chain reaction
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Gene pool
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Genomics
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Sequence alignment
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Variant genotypes
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