Removing Batch Effects in Analysis of Expression Microarray Data: An Evaluation of Six Batch Adjustment Methods

Open Access

Peer-reviewed

Research Article

Chao Chen,

Affiliations National Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai, People's Republic of China, Department of Psychiatry, University of Chicago, Chicago, Illinois, United States of America
⨯
Kay Grennan,

Affiliation Department of Psychiatry, University of Chicago, Chicago, Illinois, United States of America
⨯
Judith Badner,

Affiliation Department of Psychiatry, University of Chicago, Chicago, Illinois, United States of America
⨯
Dandan Zhang,

Affiliation Department of Pathology, Zhejiang University, Hangzhou, People's Republic of China
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Elliot Gershon,

Affiliation Department of Psychiatry, University of Chicago, Chicago, Illinois, United States of America
⨯
Li Jin,

Affiliation National Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai, People's Republic of China
⨯
Chunyu Liu

* E-mail: cliu@yoda.bsd.uchicago.edu

Affiliation Department of Psychiatry, University of Chicago, Chicago, Illinois, United States of America
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Microarrays
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Gene expression
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Singular value decomposition
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Preprocessing
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Principal component analysis
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