Histidine Hydrogen-Deuterium Exchange Mass Spectrometry for Probing the Microenvironment of Histidine Residues in Dihydrofolate Reductase

• Masaru Miyagi ,

  Contributed equally to this work with: Masaru Miyagi, Qun Wan

  * E-mail: masaru.miyagi@case.edu (MM); chris.dealwis@case.edu (CD)

  Affiliations Case Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Qun Wan ,

  Contributed equally to this work with: Masaru Miyagi, Qun Wan

  Affiliation Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Md. Faiz Ahmad,

  Affiliation Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Giridharan Gokulrangan,

  Affiliation Case Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Sara E. Tomechko,

  Affiliation Case Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Brad Bennett,

  Current address: Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

  Affiliation Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Chris Dealwis

  * E-mail: masaru.miyagi@case.edu (MM); chris.dealwis@case.edu (CD)

  Affiliations Case Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, United States of America

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