A DNA Vaccine Encoding Multiple HIV CD4 Epitopes Elicits Vigorous Polyfunctional, Long-Lived CD4+ and CD8+ T Cell Responses

Daniela Santoro Rosa; Susan Pereira Ribeiro; Rafael Ribeiro Almeida; Eliane Conti Mairena; Edilberto Postól; Jorge Kalil; Edecio Cunha-Neto

doi:10.1371/journal.pone.0016921

Loading metrics

Open Access

Peer-reviewed

Research Article

A DNA Vaccine Encoding Multiple HIV CD4 Epitopes Elicits Vigorous Polyfunctional, Long-Lived CD4⁺ and CD8⁺ T Cell Responses

Daniela Santoro Rosa ,

Contributed equally to this work with: Daniela Santoro Rosa, Susan Pereira Ribeiro

Affiliations Laboratory of Clinical Immunology and Allergy-LIM60, Division of Clinical Immunology and Allergy, Department of Medicine, University of São Paulo School of Medicine, São Paulo, Brazil, Institute for Investigation in Immunology-INCT, São Paulo, Brazil, Division of Immunology-Federal University of São Paulo-UNIFESP, São Paulo, Brazil
⨯
Susan Pereira Ribeiro ,

Contributed equally to this work with: Daniela Santoro Rosa, Susan Pereira Ribeiro

Affiliations Laboratory of Clinical Immunology and Allergy-LIM60, Division of Clinical Immunology and Allergy, Department of Medicine, University of São Paulo School of Medicine, São Paulo, Brazil, Institute for Investigation in Immunology-INCT, São Paulo, Brazil
⨯
Rafael Ribeiro Almeida,

Affiliation Laboratory of Clinical Immunology and Allergy-LIM60, Division of Clinical Immunology and Allergy, Department of Medicine, University of São Paulo School of Medicine, São Paulo, Brazil
⨯
Eliane Conti Mairena,

Affiliations Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo, Brazil, Institute for Investigation in Immunology-INCT, São Paulo, Brazil
⨯
Edilberto Postól,

Affiliations Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo, Brazil, Institute for Investigation in Immunology-INCT, São Paulo, Brazil
⨯
Jorge Kalil,

Affiliations Laboratory of Clinical Immunology and Allergy-LIM60, Division of Clinical Immunology and Allergy, Department of Medicine, University of São Paulo School of Medicine, São Paulo, Brazil, Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo, Brazil, Institute for Investigation in Immunology-INCT, São Paulo, Brazil
⨯
Edecio Cunha-Neto

* E-mail: edecunha@gmail.com

Affiliations Laboratory of Clinical Immunology and Allergy-LIM60, Division of Clinical Immunology and Allergy, Department of Medicine, University of São Paulo School of Medicine, São Paulo, Brazil, Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo, Brazil, Institute for Investigation in Immunology-INCT, São Paulo, Brazil
⨯

A DNA Vaccine Encoding Multiple HIV CD4 Epitopes Elicits Vigorous Polyfunctional, Long-Lived CD4⁺ and CD8⁺ T Cell Responses

Daniela Santoro Rosa,
Susan Pereira Ribeiro,
Rafael Ribeiro Almeida,
Eliane Conti Mairena,
Edilberto Postól,
Jorge Kalil,
Edecio Cunha-Neto

Published: February 11, 2011
https://doi.org/10.1371/journal.pone.0016921

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
HIV vaccines
Is the Subject Area "HIV vaccines" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
HIV-1
Is the Subject Area "HIV-1" applicable to this article?

Thanks for your feedback.
Immune response
Is the Subject Area "Immune response" applicable to this article?

Thanks for your feedback.
Viral vaccines
Is the Subject Area "Viral vaccines" applicable to this article?

Thanks for your feedback.
HIV
Is the Subject Area "HIV" applicable to this article?

Thanks for your feedback.