2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP+-Dependent Isocitrate Dehydrogenase Mutations

Genglin Jin; Zachary J. Reitman; Ivan Spasojevic; Ines Batinic-Haberle; Jian Yang; Oleg Schmidt-Kittler; Darell D. Bigner; Hai Yan

doi:10.1371/journal.pone.0016812

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Research Article

2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP⁺-Dependent Isocitrate Dehydrogenase Mutations

Genglin Jin ,

Contributed equally to this work with: Genglin Jin, Zachary J. Reitman

Affiliation The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, and Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Zachary J. Reitman ,

Contributed equally to this work with: Genglin Jin, Zachary J. Reitman

Affiliation The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, and Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Ivan Spasojevic,

Affiliation Clinical Pharmacology Laboratory, Department of Medicine, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Ines Batinic-Haberle,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Jian Yang,

Affiliation The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Oleg Schmidt-Kittler,

Affiliation The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Darell D. Bigner,

Affiliation The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, and Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Hai Yan

* E-mail: yan00002@mc.duke.edu

Affiliation The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, and Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP⁺-Dependent Isocitrate Dehydrogenase Mutations

Genglin Jin,
Zachary J. Reitman,
Ivan Spasojevic,
Ines Batinic-Haberle,
Jian Yang,
Oleg Schmidt-Kittler,
Darell D. Bigner,
Hai Yan

Published: February 4, 2011
https://doi.org/10.1371/journal.pone.0016812

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