Constrained Pattern of Viral Evolution in Acute and Early HCV Infection Limits Viral Plasticity

Katja Pfafferott; Silvana Gaudieri; Axel Ulsenheimer; Ian James; Malte Heeg; David Nolan; Mina John; Andri Rauch; Simon Mallal; Andrew Lucas; Paul Klenerman; Helmut M. Diepolder; Michaela Lucas

doi:10.1371/journal.pone.0016797

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Open Access

Peer-reviewed

Research Article

Constrained Pattern of Viral Evolution in Acute and Early HCV Infection Limits Viral Plasticity

Katja Pfafferott ,

Contributed equally to this work with: Katja Pfafferott, Silvana Gaudieri

Affiliation Centre for Clinical Immunology and Biomedical Statistics, Institute for Immunology & Infectious Diseases, Murdoch University and Royal Perth Hospital, Perth, Australia
⨯
Silvana Gaudieri ,

Contributed equally to this work with: Katja Pfafferott, Silvana Gaudieri

Affiliations Centre for Clinical Immunology and Biomedical Statistics, Institute for Immunology & Infectious Diseases, Murdoch University and Royal Perth Hospital, Perth, Australia, School of Anatomy and Human Biology and Centre for Forensic Science, University of Western Australia, Perth, Australia
⨯
Axel Ulsenheimer,

Affiliation Medical Department II and Institute for Immunology, Ludwig-Maximilians-University Munich, Munich, Germany
⨯
Ian James,

Affiliation Centre for Clinical Immunology and Biomedical Statistics, Institute for Immunology & Infectious Diseases, Murdoch University and Royal Perth Hospital, Perth, Australia
⨯
Malte Heeg,

Affiliation Medical Department II and Institute for Immunology, Ludwig-Maximilians-University Munich, Munich, Germany
⨯
David Nolan,

Affiliation Centre for Clinical Immunology and Biomedical Statistics, Institute for Immunology & Infectious Diseases, Murdoch University and Royal Perth Hospital, Perth, Australia
⨯
Mina John,

Affiliation Centre for Clinical Immunology and Biomedical Statistics, Institute for Immunology & Infectious Diseases, Murdoch University and Royal Perth Hospital, Perth, Australia
⨯
Andri Rauch,

Affiliations Centre for Clinical Immunology and Biomedical Statistics, Institute for Immunology & Infectious Diseases, Murdoch University and Royal Perth Hospital, Perth, Australia, University Hospital Berne and University of Berne, Berne, Switzerland
⨯
Simon Mallal,

Affiliation Centre for Clinical Immunology and Biomedical Statistics, Institute for Immunology & Infectious Diseases, Murdoch University and Royal Perth Hospital, Perth, Australia
⨯
Andrew Lucas,

Affiliation Centre for Clinical Immunology and Biomedical Statistics, Institute for Immunology & Infectious Diseases, Murdoch University and Royal Perth Hospital, Perth, Australia
⨯
Paul Klenerman,

Affiliation Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom
⨯
Helmut M. Diepolder,

Affiliation Medical Department II and Institute for Immunology, Ludwig-Maximilians-University Munich, Munich, Germany
⨯
Michaela Lucas

* E-mail: michaela.lucas@health.wa.gov.au

Affiliation Centre for Clinical Immunology and Biomedical Statistics, Institute for Immunology & Infectious Diseases, Murdoch University and Royal Perth Hospital, Perth, Australia
⨯

Constrained Pattern of Viral Evolution in Acute and Early HCV Infection Limits Viral Plasticity

Katja Pfafferott,
Silvana Gaudieri,
Axel Ulsenheimer,
Ian James,
Malte Heeg,
David Nolan,
Mina John,
Andri Rauch,
Simon Mallal,
Andrew Lucas

Published: February 8, 2011
https://doi.org/10.1371/journal.pone.0016797

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