Epistasis between COMT and MTHFR in Maternal-Fetal Dyads Increases Risk for Preeclampsia

Lori D. Hill; Timothy P. York; Juan P. Kusanovic; Ricardo Gomez; Lindon J. Eaves; Roberto Romero; Jerome F. Strauss III

doi:10.1371/journal.pone.0016681

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Open Access

Peer-reviewed

Research Article

Epistasis between COMT and MTHFR in Maternal-Fetal Dyads Increases Risk for Preeclampsia

Lori D. Hill,

Affiliation Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
⨯
Timothy P. York,

Affiliations Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
⨯
Juan P. Kusanovic,

Affiliations Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, United States of America, Department of Obstetrics and Gynecology, Sótero del Río Hospital, Santiago, Chile, Department of Obstetrics and Gynecology, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯
Ricardo Gomez,

Affiliations Department of Obstetrics and Gynecology, Sótero del Río Hospital, Santiago, Chile, Department of Obstetrics and Gynecology, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯
Lindon J. Eaves,

Affiliations Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
⨯
Roberto Romero,

Affiliation Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
⨯
Jerome F. Strauss III

* E-mail: jfstrauss@vcu.edu

Affiliation Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
⨯

Epistasis between COMT and MTHFR in Maternal-Fetal Dyads Increases Risk for Preeclampsia

Lori D. Hill,
Timothy P. York,
Juan P. Kusanovic,
Ricardo Gomez,
Lindon J. Eaves,
Roberto Romero,
Jerome F. Strauss III

Published: January 31, 2011
https://doi.org/10.1371/journal.pone.0016681

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