G12/13 Signaling Pathways Substitute for Integrin αIIbβ3-Signaling for Thromboxane Generation in Platelets

Kamala Bhavaraju; Parth R. Lakhani; Robert T. Dorsam; Jianguo Jin; Ian S. Hitchcock; Archana Sanjay; Satya P. Kunapuli

doi:10.1371/journal.pone.0016586

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Peer-reviewed

Research Article

G_12/13 Signaling Pathways Substitute for Integrin αIIbβ3-Signaling for Thromboxane Generation in Platelets

Kamala Bhavaraju,

Affiliations Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Sol Sherry Thrombosis Research Center, Temple University, Philadelphia, Pennsylvania, United States of America
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Parth R. Lakhani,

Affiliation Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Robert T. Dorsam,

Affiliations Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Sol Sherry Thrombosis Research Center, Temple University, Philadelphia, Pennsylvania, United States of America
⨯
Jianguo Jin,

Affiliations Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Sol Sherry Thrombosis Research Center, Temple University, Philadelphia, Pennsylvania, United States of America
⨯
Ian S. Hitchcock,

Affiliation Department of Medicine, University of California San Diego, La Jolla, California, United States of America
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Archana Sanjay,

Affiliation Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Satya P. Kunapuli

* E-mail: spk@temple.edu

Affiliations Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Sol Sherry Thrombosis Research Center, Temple University, Philadelphia, Pennsylvania, United States of America
⨯

G_12/13 Signaling Pathways Substitute for Integrin αIIbβ3-Signaling for Thromboxane Generation in Platelets

Kamala Bhavaraju,
Parth R. Lakhani,
Robert T. Dorsam,
Jianguo Jin,
Ian S. Hitchcock,
Archana Sanjay,
Satya P. Kunapuli

Published: February 10, 2011
https://doi.org/10.1371/journal.pone.0016586

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Integrins
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Thromboxane
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Platelet activation
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Tyrosine kinases
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Platelets
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Tyrosine kinase signaling cascade
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