Mucosal Targeting of a BoNT/A Subunit Vaccine Adjuvanted with a Mast Cell Activator Enhances Induction of BoNT/A Neutralizing Antibodies in Rabbits

Herman F. Staats; Jeffrey R. Fielhauer; Afton L. Thompson; Alice A. Tripp; Ashley E. Sobel; Massimo Maddaloni; Soman N. Abraham; David W. Pascual

doi:10.1371/journal.pone.0016532

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Peer-reviewed

Research Article

Mucosal Targeting of a BoNT/A Subunit Vaccine Adjuvanted with a Mast Cell Activator Enhances Induction of BoNT/A Neutralizing Antibodies in Rabbits

Herman F. Staats ,

* E-mail: herman.staats@duke.edu

Affiliations Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America, Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Jeffrey R. Fielhauer,

Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Afton L. Thompson,

Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Alice A. Tripp,

Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Ashley E. Sobel,

Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Massimo Maddaloni,

Affiliation Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America
⨯
Soman N. Abraham,

Affiliations Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
David W. Pascual

Affiliation Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America
⨯

Mucosal Targeting of a BoNT/A Subunit Vaccine Adjuvanted with a Mast Cell Activator Enhances Induction of BoNT/A Neutralizing Antibodies in Rabbits

Herman F. Staats,
Jeffrey R. Fielhauer,
Afton L. Thompson,
Alice A. Tripp,
Ashley E. Sobel,
Massimo Maddaloni,
Soman N. Abraham,
David W. Pascual

Published: January 27, 2011
https://doi.org/10.1371/journal.pone.0016532

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