Cathepsin-D, a Key Protease in Breast Cancer, Is Up-Regulated in Obese Mouse and Human Adipose Tissue, and Controls Adipogenesis

Olivier Masson; Christine Prébois; Danielle Derocq; Aline Meulle; Cédric Dray; Danielle Daviaud; Didier Quilliot; Philippe Valet; Catherine Muller; Emmanuelle Liaudet-Coopman

doi:10.1371/journal.pone.0016452

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Research Article

Cathepsin-D, a Key Protease in Breast Cancer, Is Up-Regulated in Obese Mouse and Human Adipose Tissue, and Controls Adipogenesis

Olivier Masson,

Affiliations IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France, INSERM, U896, Montpellier, France, Université Montpellier 1, Montpellier, France, CRLC Val d'Aurelle Paul Lamarque, Montpellier, France
⨯
Christine Prébois,

Affiliations IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France, INSERM, U896, Montpellier, France, Université Montpellier 1, Montpellier, France, CRLC Val d'Aurelle Paul Lamarque, Montpellier, France
⨯
Danielle Derocq,

Affiliations IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France, INSERM, U896, Montpellier, France, Université Montpellier 1, Montpellier, France, CRLC Val d'Aurelle Paul Lamarque, Montpellier, France
⨯
Aline Meulle,

Affiliations Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, Toulouse, France, Institute of Pharmacology and Structural Biology CNRS UMR 5089, Toulouse, France, Université de Toulouse, Toulouse, France
⨯
Cédric Dray,

Affiliations Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, Toulouse, France, INSERM, U858, Toulouse, France
⨯
Danielle Daviaud,

Affiliations Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, Toulouse, France, INSERM, U858, Toulouse, France
⨯
Didier Quilliot,

Affiliation Service de diabétologie, Maladies métaboliques et nutrition, CHU de Nancy, Nancy, France
⨯
Philippe Valet,

Affiliations Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, Toulouse, France, INSERM, U858, Toulouse, France
⨯
Catherine Muller,

Affiliations Institute of Pharmacology and Structural Biology CNRS UMR 5089, Toulouse, France, Université de Toulouse, Toulouse, France
⨯
Emmanuelle Liaudet-Coopman

* E-mail: e.liaudet@valdorel.fnclcc.fr

Affiliations IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France, INSERM, U896, Montpellier, France, Université Montpellier 1, Montpellier, France, CRLC Val d'Aurelle Paul Lamarque, Montpellier, France
⨯

Cathepsin-D, a Key Protease in Breast Cancer, Is Up-Regulated in Obese Mouse and Human Adipose Tissue, and Controls Adipogenesis

Olivier Masson,
Christine Prébois,
Danielle Derocq,
Aline Meulle,
Cédric Dray,
Danielle Daviaud,
Didier Quilliot,
Philippe Valet,
Catherine Muller,
Emmanuelle Liaudet-Coopman

Published: February 2, 2011
https://doi.org/10.1371/journal.pone.0016452

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Adipocytes
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Adipocyte differentiation
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Obesity
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Adipose tissue
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Breast cancer
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Lipids
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Protein expression
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