Molecular Evolutionary Analysis of ABCB5: The Ancestral Gene Is a Full Transporter with Potentially Deleterious Single Nucleotide Polymorphisms

Open Access

Peer-reviewed

Research Article

Karobi Moitra ,

Contributed equally to this work with: Karobi Moitra, Mark Scally

Affiliation Laboratory of Experimental Immunology, Human Genetics Section, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
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Mark Scally ,

Contributed equally to this work with: Karobi Moitra, Mark Scally

Affiliation Laboratory of Experimental Immunology, Human Genetics Section, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
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Kate McGee,

Affiliation Laboratory of Experimental Immunology, Human Genetics Section, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
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Germaine Lancaster,

Affiliation Laboratory of Experimental Immunology, Human Genetics Section, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
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Bert Gold,

Affiliation Laboratory of Experimental Immunology, Human Genetics Section, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
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Michael Dean

* E-mail: deanm@mail.nih.gov

Affiliation Laboratory of Experimental Immunology, Human Genetics Section, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
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Computer software
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Single nucleotide polymorphisms
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Sequence motif analysis
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Melanoma
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Panthers
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Protein structure
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Animal evolution
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Phylogenetic analysis
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