Down-Regulation of miR-101 in Endothelial Cells Promotes Blood Vessel Formation through Reduced Repression of EZH2

Michiel Smits; Shahryar E. Mir; R. Jonas A. Nilsson; Petra M. van der Stoop; Johanna M. Niers; Victor E. Marquez; Jacqueline Cloos; Xandra O. Breakefield; Anna M. Krichevsky; David P. Noske; Bakhos A. Tannous; Thomas Würdinger

doi:10.1371/journal.pone.0016282

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Open Access

Peer-reviewed

Research Article

Down-Regulation of miR-101 in Endothelial Cells Promotes Blood Vessel Formation through Reduced Repression of EZH2

Michiel Smits ,

Contributed equally to this work with: Michiel Smits, Shahryar E. Mir

Affiliation Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
⨯
Shahryar E. Mir ,

Contributed equally to this work with: Michiel Smits, Shahryar E. Mir

Affiliation Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
⨯
R. Jonas A. Nilsson,

Affiliation Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
⨯
Petra M. van der Stoop,

Affiliation Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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Johanna M. Niers,

Affiliations Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, Molecular Neurogenetics Unit, Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, United States of America
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Victor E. Marquez,

Affiliation Center for Cancer Research, National Cancer Institute at Frederick (NCI-Frederick), Frederick, Maryland, United States of America
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Jacqueline Cloos,

Affiliation Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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Xandra O. Breakefield,

Affiliation Molecular Neurogenetics Unit, Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, United States of America
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Anna M. Krichevsky,

Affiliation Department of Neurology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
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David P. Noske,

Affiliation Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
⨯
Bakhos A. Tannous,

Affiliation Molecular Neurogenetics Unit, Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Thomas Würdinger

* E-mail: t.wurdinger@vumc.nl

Affiliations Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, Molecular Neurogenetics Unit, Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Down-Regulation of miR-101 in Endothelial Cells Promotes Blood Vessel Formation through Reduced Repression of EZH2

Michiel Smits,
Shahryar E. Mir,
R. Jonas A. Nilsson,
Petra M. van der Stoop,
Johanna M. Niers,
Victor E. Marquez,
Jacqueline Cloos,
Xandra O. Breakefield,
Anna M. Krichevsky,
David P. Noske

Published: January 28, 2011
https://doi.org/10.1371/journal.pone.0016282

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Small interfering RNA
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Blood vessels
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