Lysine Auxotrophy Combined with Deletion of the SecA2 Gene Results in a Safe and Highly Immunogenic Candidate Live Attenuated Vaccine for Tuberculosis

Joseph Hinchey; Bo Y. Jeon; Holly Alley; Bing Chen; Michael Goldberg; Steven Derrick; Sheldon Morris; William R. Jacobs Jr; Steven A. Porcelli; Sunhee Lee

doi:10.1371/journal.pone.0015857

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Open Access

Peer-reviewed

Research Article

Lysine Auxotrophy Combined with Deletion of the SecA2 Gene Results in a Safe and Highly Immunogenic Candidate Live Attenuated Vaccine for Tuberculosis

Joseph Hinchey,

Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Bo Y. Jeon,

Affiliation Department of Microbiology, Yonsei University College of Medicine, Seoul, Republic of Korea
⨯
Holly Alley,

Affiliation Duke Human Vaccine Institute, Durham, North Carolina, United States of America
⨯
Bing Chen,

Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Michael Goldberg,

Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Steven Derrick,

Affiliation Center for Biologics Evaluation, US Food and Drug Administration, Bethesda, Maryland, United States of America
⨯
Sheldon Morris,

Affiliation Center for Biologics Evaluation, US Food and Drug Administration, Bethesda, Maryland, United States of America
⨯
William R. Jacobs Jr,

Affiliations Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Steven A. Porcelli,

Affiliations Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Sunhee Lee

* E-mail: sunhee.lee@duke.edu

Affiliation Duke Human Vaccine Institute, Durham, North Carolina, United States of America
⨯

Lysine Auxotrophy Combined with Deletion of the SecA2 Gene Results in a Safe and Highly Immunogenic Candidate Live Attenuated Vaccine for Tuberculosis

Joseph Hinchey,
Bo Y. Jeon,
Holly Alley,
Bing Chen,
Michael Goldberg,
Steven Derrick,
Sheldon Morris,
William R. Jacobs Jr,
Steven A. Porcelli,
Sunhee Lee

Published: January 10, 2011
https://doi.org/10.1371/journal.pone.0015857

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