Crystal Structure of the Pyrazinamidase of Mycobacterium tuberculosis: Insights into Natural and Acquired Resistance to Pyrazinamide

Open Access

Peer-reviewed

Research Article

Stéphanie Petrella,

Affiliation UPMC Université Paris 6, ER 5 (EA1541) Bactériologie-Hygiène, Faculté de Médecine Pitié-Salpêtrière, Paris, France
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Nathalie Gelus-Ziental,

Affiliations UPMC Université Paris 6, ER 5 (EA1541) Bactériologie-Hygiène, Faculté de Médecine Pitié-Salpêtrière, Paris, France, INSERM, U908 et FRE3249 CNRS, Université Lille I, Villeneuve d'Ascq, France
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Arnaud Maudry,

Affiliation UPMC Université Paris 6, ER 5 (EA1541) Bactériologie-Hygiène, Faculté de Médecine Pitié-Salpêtrière, Paris, France
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Caroline Laurans,

Affiliations UPMC Université Paris 6, ER 5 (EA1541) Bactériologie-Hygiène, Faculté de Médecine Pitié-Salpêtrière, Paris, France, Equipe Opérationnelle d'Hygiène et d'Infectiologie, Centre Hospitalier Victor Provo, Roubaix, France
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Rachid Boudjelloul,

Affiliation UPMC Université Paris 6, ER 5 (EA1541) Bactériologie-Hygiène, Faculté de Médecine Pitié-Salpêtrière, Paris, France
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Wladimir Sougakoff

* E-mail: wladimir.sougakoff@upmc.fr

Affiliations UPMC Université Paris 6, ER 5 (EA1541) Bactériologie-Hygiène, Faculté de Médecine Pitié-Salpêtrière, Paris, France, INSERM, UMRS-872-12 Pitié-Salpêtrière, LRMA, Paris, France
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Crystal structure
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Mycobacterium tuberculosis
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Root structure
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Enzyme structure
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Iron
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Point mutation
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Protein folding
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Thermal stability
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