NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways

Huiping Yuan; Xiaoyong Zhang; Xiuqing Huang; Yonggang Lu; Weiqing Tang; Yong Man; Shu Wang; Jianzhong Xi; Jian Li

doi:10.1371/journal.pone.0015726

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Peer-reviewed

Research Article

NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways

Huiping Yuan ,

Contributed equally to this work with: Huiping Yuan, Xiaoyong Zhang

Affiliations Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China, Peking University Fifth School of Clinical Medicine, Beijing Hospital, Beijing, China
⨯
Xiaoyong Zhang ,

Contributed equally to this work with: Huiping Yuan, Xiaoyong Zhang

Affiliation Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Xiuqing Huang,

Affiliation Peking University Fifth School of Clinical Medicine, Beijing Hospital, Beijing, China
⨯
Yonggang Lu,

Affiliation Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Weiqing Tang,

Affiliation Peking University Fifth School of Clinical Medicine, Beijing Hospital, Beijing, China
⨯
Yong Man,

Affiliation Peking University Fifth School of Clinical Medicine, Beijing Hospital, Beijing, China
⨯
Shu Wang,

Affiliation Peking University Fifth School of Clinical Medicine, Beijing Hospital, Beijing, China
⨯
Jianzhong Xi ,

* E-mail: lijian@bjhmoh.cn (JL); jzxi@pku.edu.cn (JX)

Affiliation Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China
⨯
Jian Li

* E-mail: lijian@bjhmoh.cn (JL); jzxi@pku.edu.cn (JX)

Affiliations Peking University Fifth School of Clinical Medicine, Beijing Hospital, Beijing, China, Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯

NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways

Huiping Yuan,
Xiaoyong Zhang,
Xiuqing Huang,
Yonggang Lu,
Weiqing Tang,
Yong Man,
Shu Wang,
Jianzhong Xi,
Jian Li

Published: December 29, 2010
https://doi.org/10.1371/journal.pone.0015726

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