High-Definition Mapping of Retroviral Integration Sites Defines the Fate of Allogeneic T Cells After Donor Lymphocyte Infusion

Claudia Cattoglio; Giulietta Maruggi; Cynthia Bartholomae; Nirav Malani; Danilo Pellin; Fabienne Cocchiarella; Zulma Magnani; Fabio Ciceri; Alessandro Ambrosi; Christof von Kalle; Frederic D. Bushman; Chiara Bonini; Manfred Schmidt; Fulvio Mavilio; Alessandra Recchia

doi:10.1371/journal.pone.0015688

Loading metrics

Open Access

Peer-reviewed

Research Article

High-Definition Mapping of Retroviral Integration Sites Defines the Fate of Allogeneic T Cells After Donor Lymphocyte Infusion

Claudia Cattoglio,

Affiliation IIT Unit of Molecular Neuroscience, Istituto Scientifico H. San Raffaele, Milan, Italy
⨯
Giulietta Maruggi,

Affiliation Center for Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
⨯
Cynthia Bartholomae,

Affiliation Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Nirav Malani,

Affiliation Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Danilo Pellin,

Affiliation Center for Statistics in Biomedical Sciences, Università Vita-Salute San Raffaele, Milan, Italy
⨯
Fabienne Cocchiarella,

Affiliation Center for Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
⨯
Zulma Magnani,

Affiliation Experimental Hematology Unit, PIBIC, Division of Regenerative Medicine, Gene Therapy and Stem Cells, Istituto Scientifico H. San Raffaele, Milan, Italy
⨯
Fabio Ciceri,

Affiliation Hematology Unit, Istituto Scientifico H. San Raffaele, Milan, Italy
⨯
Alessandro Ambrosi,

Affiliation Center for Statistics in Biomedical Sciences, Università Vita-Salute San Raffaele, Milan, Italy
⨯
Christof von Kalle,

Affiliation Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Frederic D. Bushman,

Affiliation Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Chiara Bonini,

Affiliation Experimental Hematology Unit, PIBIC, Division of Regenerative Medicine, Gene Therapy and Stem Cells, Istituto Scientifico H. San Raffaele, Milan, Italy
⨯
Manfred Schmidt,

Affiliation Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Fulvio Mavilio,

Affiliations IIT Unit of Molecular Neuroscience, Istituto Scientifico H. San Raffaele, Milan, Italy, Center for Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
⨯
Alessandra Recchia

* E-mail: alessandra.recchia@unimore.it

Affiliation Center for Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
⨯

High-Definition Mapping of Retroviral Integration Sites Defines the Fate of Allogeneic T Cells After Donor Lymphocyte Infusion

Claudia Cattoglio,
Giulietta Maruggi,
Cynthia Bartholomae,
Nirav Malani,
Danilo Pellin,
Fabienne Cocchiarella,
Zulma Magnani,
Fabio Ciceri,
Alessandro Ambrosi,
Christof von Kalle

Published: December 22, 2010
https://doi.org/10.1371/journal.pone.0015688

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
DNA transcription
Is the Subject Area "DNA transcription" applicable to this article?

Thanks for your feedback.
Genomics
Is the Subject Area "Genomics" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Human genomics
Is the Subject Area "Human genomics" applicable to this article?

Thanks for your feedback.
Epigenetics
Is the Subject Area "Epigenetics" applicable to this article?

Thanks for your feedback.
Histone modification
Is the Subject Area "Histone modification" applicable to this article?

Thanks for your feedback.
Genetic loci
Is the Subject Area "Genetic loci" applicable to this article?

Thanks for your feedback.